1,4-Dioxane hydrochloride → HCID 70084157, compound

HRID 618176Notes

Reaction equation

HRID 618176 reaction equation
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][C@H:6]([NH:13][C:14](=[O:31])[CH2:15][NH:16][C:17](=[O:30])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22]C(OC(C)(C)C)=O)[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[CH3:2].[ClH:33].O1CCOCC1>>[ClH:33].[ClH:33].[CH2:1]([O:3][C:4](=[O:32])[CH2:5][C@H:6]([NH:13][C:14](=[O:31])[CH2:15][NH:16][C:17](=[O:30])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 70072839HCID 70072839, compound

Product 1

HCID 70084157HCID 70084157, compound

Procedure

A 4M HCl/dioxane solution(10 mL) of 24-3 (101 mg, 0.24 mmol) was stirred under ambient conditions for 18 hr. The solution was concentrated to provide 24-4 as a pale yellow gum which was used in the next step without further purification.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-708a246efd264b79ac74056aa1085d0a
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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