Ammonium Hydroxide → HCID 54361786, compound

Participants

Reaction Steps

To a solution of (3R,4R)-1-benzyl-3,4-dibenzyloxypyrrolidine (26.8 g, 71.7 mmol) in methanol (600 ml) was added palladium hydroxide on activated charcoal (20% Pd, 2,7 g) and 25% ammonium hydroxide (6 ml). The mixture was hydrogenated in a Parr apparatus at 20 psi for 20 hours. The mixture was filtered and evaporated to dryness in vacuo to give (3R,4R)-3,4-dibenzyloxypyrrolidine (19.7 g, yield: 96%) as an oil.

Provenance & Evidence