Hydrochloric Acid → HCID 53898895, compound

Participants

Reaction Steps

To a solution of (3R,4R)-1-benzyl-3,4-dibenzyloxy-2-(1-hydroxyethyl)pyrrolidine (90 mg, 0.22 mmol) in abs. ethanol (10 ml) was added palladium on activated charcoal (10% Pd, 30 mg) and 37% hydrochloric acid (0.1 ml). The mixture was hydrogenated in a Parr apparatus at 40 psi for 20 hours. The mixture was filtered and evaporated to dryness in vacuo to give (3R,4R)-2-(1-hydroxyethyl)-3,4-pyrrolidinediol (36 mg, yield: 90%) as an oil.

Provenance & Evidence