反应详情

2-(3-Methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride (0.8 g) was suspended in 12 ml of absolute methanol (MeOH) and treated with 0.16 g of ethylene diamine. After 8 hours at room temperature the solvent was evaporated. The residue was purified by silica gel chromatography eluting with methanol:dichloromethane:ammonium hydroxide (16:84:0.1). Conversion to the hydrochloride salt by addition of 1.0M hydrogen chloride in ether gave 0.16 g of N-[3-(4,5-dihydro-1H-imidazol-2-ylmethoxy)phenyl]methanesulfonamide hydrochloride, mp 183-187° C.

1. customAfter 8 hours at room temperature the solvent was evaporated
2. customThe residue was purified by silica gel chromatography
3. washeluting with methanol:dichloromethane:ammonium hydroxide (16:84:0.1)
4. additionConversion to the hydrochloride salt by addition of 1.0M hydrogen chloride in ether