HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → N-(5-cyanomethoxy-2-methylphenyl)-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (3-Amino-4-methylphenoxy) acetonitrile | HCID 18789626 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(5-cyanomethoxy-2-methylphenyl)-methanesulfonamide | HCID 18789597 | 90.9% |
Reaction Conditions
| Temperature | 5 °C |
|---|
Reaction Steps
(3-Amino-4-methylphenoxy)-acetonitrile (2.6 g) was dissolved in 10 ml of pyridine, cooled in an ice bath; 2.29 g of methanesulfonyl chloride was added; and the reaction mixture was stirred at 5° C. for 1 hour. The mixture was poured into ethyl acetate, washed with hydrochloric acid, then water, dried, and evaporated giving 3.5 g of N-(5-cyanomethoxy-2-methylphenyl)-methanesulfonamide. ##STR66##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952362 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-dec7e4d13b9d403d931a51e581c43207 |
| Source note | uspto-grants-1999_09 |