HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → (3-Amino-4-benzyloxy-phenoxy)-acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (4-Benzyloxy-3-nitro-phenoxy)-acetonitrile | HCID 18789746 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (3-Amino-4-benzyloxy-phenoxy)-acetonitrile | HCID 18789661 | 97.2% |
Reaction Steps
A solution of 6.9 g (4-benzyloxy-3-nitro-phenoxy)-acetonitrile, 200 ml of ethyl acetate, and 27.4 g of tin (II) chloride dihydrate was stirred at room temperature for 17 hours, poured into ethyl acetate, added saturated sodium bicarbonate solution, extracted twice with ethyl acetate, dried (MgSO4), evaporated, and obtained 6.0 g of (3-amino-4-benzyloxy-phenoxy)-acetonitrile as a light brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952362 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-80eaed4f1a424fa2a64c88d986083ccd |
| Source note | uspto-grants-1999_09 |