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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618248Generated: October 29, 2026

N-methanesulfonyl-6-bromomethylindole → (3-Chloro-4-methyl-5-nitrophenyl) acetonitrile

https://huagongshe.com/reaction/618248

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methanesulfonyl-6-bromomethylindoleHCID 18789641—
ReactantN-methanesulfonyl-6-cyanomethylindoleHCID 18789651—
Reactant5-Bromomethyl-1-chloro-2-methyl-3-nitrobenzeneHCID 18789673—
Product(3-Chloro-4-methyl-5-nitrophenyl) acetonitrileHCID 54125367—

Reaction Steps

(3-Chloro-4-methyl-5-nitrophenyl) acetonitrile was prepared from 5-bromomethyl-1-chloro-2-methyl-3-nitrobenzene in a manner similar to that described in Example 10 for the preparation of N-methanesulfonyl-6-cyanomethyl indole from N-methanesulfonyl-6-bromomethyl indole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952362
Source datasetuspto-grants-1999_09
ORD IDord-676736df6b6444108f6ee02c07214050
Source noteuspto-grants-1999_09