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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618251Generated: October 30, 2026

2-(3-Aminophenoxy)acetonitrile → N-[3-chloro-5-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylphenyl]methanesulfonamide hydrochloride

https://huagongshe.com/reaction/618251

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Aminophenoxy)acetonitrileHCID 18789699—
ReactantHCID 18789725HCID 18789725—
ReactantN-(3-chloro-5-cyanomethyl-2-methylphenyl) methanesulfonamideHCID 53903521—
ProductN-[3-chloro-5-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylphenyl]methanesulfonamide hydrochlorideHCID 18789717—

Reaction Steps

N-[3-chloro-5-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylphenyl]methanesulfonamide hydrochloride (mp 256.2-256.7° C.) was prepared from N-(3-chloro-5-cyanomethyl-2-methylphenyl) methanesulfonamide in a manner similar to that described in Example 1 for the preparation of N-[3-(4,5-dihydro-1H-imidazol-2-ylmethoxy)phenyl]methanesulfonamide hydrochloride from (3-aminophenoxy)acetonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952362
Source datasetuspto-grants-1999_09
ORD IDord-3d03f158ac544cda9c00f34c75596ca2
Source noteuspto-grants-1999_09