2-Methyl-3-nitroaniline → HCID 4433548, compound

HRID 618252Notes

Reaction equation

HRID 618252 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[NH2:11].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>N1C=CC=CC=1>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:11][S:13]([CH3:12])(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 117832-Methyl-3-nitroanilineHCID 31297Methanesulfonyl chloride

Product 1

HCID 4433548HCID 4433548, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-methyl-3-nitro-phenylamine (3 g) and methanesulfonyl chloride (1.6 mL) in pyridine (30 mL, from Mallinckrodt) was stirred at room temperature overnight. Pyridine was removed under reduced pressure. The residue was taken up with dichloromethane (Mallinckrodt) and washed with water and brine. After drying over sodium sulfate and evaporation of the solvent, N-(2-Methyl-3-nitro-phenyl)-methanesulfonamide (4 g) was obtained.

Workup

  1. customPyridine was removed under reduced pressure
  2. washwashed with water and brine
  3. dry with materialAfter drying over sodium sulfate and evaporation of the solvent

Sources & evidence

ORD record
ord-b2a8126639d34a08ae8ebadc51cd673c
Source dataset
uspto-grants-1999_09
Patent number
US05952362

Reaction notes

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