HuagongsheHuagongshe Chemistry Print Report · For research reference only
Einecs 211-027-4 → 3-Chloro-4-fluoro-8-hydroxy-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Einecs 211-027-4 | HCID 69401 | — |
| Reactant | 3-Chloro-4-fluoro-8-methoxy-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one | HCID 66834585 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Chloro-4-fluoro-8-hydroxy-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one | HCID 66834646 | 66.1% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
3-Chloro-4-fluoro-8-methoxy-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one (Compound S1-3, 220.0 mg, 0.640 mmol) and pyridinium chloride (800 mg, 6.922 mmol) were mixed with each other, heated to 160° C., and then stirred for 20 hr. The reaction solution was added with water. As a result, black solid was obtained as a precipitate, which was then filtered and subjected to purification by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (139.4 mg, 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440922B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1e9df7b85ecb4c528b488c7fab8fb5bd |
| Source note | uspto-grants-2016_09 |