3,4-Dichlorophenylacetic acid → HCID 18392003, compound

HRID 618279Notes

Reaction equation

HRID 618279 reaction equation
[C:1]1([C@H:7]([NH:21][O:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][O:24]2)[CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([O:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][O:16]3)[CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:29][C:30]1[CH:31]=[C:32]([CH2:37][C:38](O)=[O:39])[CH:33]=[CH:34][C:35]=1[Cl:36]>>[Cl:29][C:30]1[CH:31]=[C:32]([CH2:37][C:38]([N:21]([O:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][O:24]2)[C@@H:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([O:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][O:16]3)[CH2:10]2)=[O:39])[CH:33]=[CH:34][C:35]=1[Cl:36]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 18391991HCID 18391991, compound

Product 1

HCID 18392003HCID 18392003, compoundYield 69.8%

Procedure

This was prepared from 1-(S)-Phenyl-N-tetrahydropyranyloxy-2-(3-(S)-tetrahydropyranyloxypyrroidin-1-yl)ethylamine and 3,4-dichlorophenylacetic acid in 69.8% yield as a clear brown Viscous oil according to a procedure similar to that described in Example 1.

Sources & evidence

ORD record
ord-b37096a0512247fc9b98153248ab9c54
Source dataset
uspto-grants-1999_09
Patent number
US05952369

Reaction notes

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