HCID 18391989, compound → (R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran

Participants

Reaction Steps

A mixture of 1-benzyl-3-(R)-tetrahydropyranyloxypyrolidine(8.78 g, 27.3 mmol) and Pearlman's catalyst (3.50 g) in MeOH (100 ml) was stirred under hydrogen atmosphere at rt for 4 h. After removal of the catalyst by Celite filtration, the filtrate was concentrated to give 5.74 g of clear light brown oil. This was used for the next reaction without purification.

Provenance & Evidence