Pyridine → HCID 54519428, compound

Participants

Reaction Steps

A solution of 4-phenylphenol (25.0 g, 0.15 mol) and pyridine (11.89 ml, 0.15 mol) in 250 ml of methylene chloride were added dropwise under nitrogen to a solution of 4-nitrophenyl chloroformate (29.65 g, 0.15 mol) in 200 ml of methylene chloride at ice bath temperature. The reaction was stirred at ice bath temperature for approximately two hours and then overnight at room temperature. The reaction was extracted one time with 1N HCl, multiple times with saturated Na2CO3, dried (MgSO4) and the solvent removed under reduced pressure to give 46.05 g of light yellow crystals. Recrystallization from methylene chloride-diisopropyl ether gave the title compound as light yellow crystals, mp 138-140° C.

Provenance & Evidence