Acetonitrile → HCID 70071560, compound

HRID 618354Notes

Reaction equation

HRID 618354 reaction equation
[NH2:1][C:2](=NO)[C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][CH:14]=2)=[O:10])[CH:6]=[CH:7][CH:8]=1.C(#[N:30])C>[Pd]>[NH2:30][N:1]=[CH:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][CH:14]=2)=[O:10])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 73753167HCID 73753167, compound

Product 1

HCID 70071560HCID 70071560, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumSolvent

Procedure

The compound of Example 13 (0.49 g, 1.3 mmol) was dissolved in ACOH and hydrogenated with 4% Pd/C (53% wet, 0.050 g) in a Parr Shaker (60 psi, 60C). The catalyst was filtered off and the filtrate concentrated in vacuo to give a white solid. The solid was slurried with acetonitrile and the resulting white solid was collected by vacuum filtration (0.423 g).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate concentrated in vacuo
  3. customto give a white solid
  4. filtrationthe resulting white solid was collected by vacuum filtration (0.423 g)

Sources & evidence

ORD record
ord-4febc61c2e03496aa33106803281bc75
Source dataset
uspto-grants-1999_09
Patent number
US05952381

Reaction notes

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