1,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxide → HCID 86754461, compound

HRID 618369Notes

Reaction equation

HRID 618369 reaction equation
[O:1]=[C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][NH:10][CH2:9][C@H:8]2[C:13]([O:15][CH3:16])=[O:14])[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1.[O:21]=[S:22]1(=[O:38])[C:26]2[CH:27]=[CH:28][C:29]([Cl:31])=[CH:30][C:25]=2[C:24](=[O:32])[N:23]1[CH2:33][CH2:34][CH2:35][CH2:36]Br>C(Cl)Cl>[O:38]=[S:22]1(=[O:21])[C:26]2[CH:27]=[CH:28][C:29]([Cl:31])=[CH:30][C:25]=2[C:24](=[O:32])[N:23]1[CH2:33][CH2:34][CH2:35][CH2:36][N:10]1[CH2:11][CH2:12][C@@H:7]([N:6]2[C:5]3[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=3[NH:3][C:2]2=[O:1])[C@H:8]([C:13]([O:15][CH3:16])=[O:14])[CH2:9]1

Participants

4

Reactant 2

HCID 133659801,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxideHCID 86754462HCID 86754462, compound

Product 1

HCID 86754461HCID 86754461, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

From (±)cis/trans-4-(2-oxo-1-benzimidazolinyl)-3-methoxycarbonyl-piperidine and 1,1-dioxido-2-(4-bromobutyl)-5-chloro-1,2-benzisothiazol-3(2H)-one (prepared as shown in Example 22) using the procedures described in Example 1, Step 3, there was obtained a white solid from methylene chloride, melting point 170-176° C. Analysis calculated for C25H27ClN4O6S: C, 54.89; H, 4.98; N, 10.24; found: C, 54.65; H, 4.98; N, 10.22. The NMR was consistent with the structure.

Sources & evidence

ORD record
ord-813878aff4cf4119bb1607786de51ef5
Source dataset
uspto-grants-1999_09
Patent number
US05952351

Reaction notes

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