1,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxide → 1,1-Dioxido-2-(4-(4-(5-fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)butyl)-5-chloro-1,2-benzisothiazol-3(2H)-one

HRID 618371Notes

Reaction equation

HRID 618371 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]([CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[C:7](=[O:11])[N:8]([CH2:9][CH3:10])[C:4]=2[CH:3]=1.[O:20]=[S:21]1(=[O:37])[C:25]2[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:24]=2[C:23](=[O:31])[N:22]1[CH2:32][CH2:33][CH2:34][CH2:35]Br>>[O:37]=[S:21]1(=[O:20])[C:25]2[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:24]=2[C:23](=[O:31])[N:22]1[CH2:32][CH2:33][CH2:34][CH2:35][N:15]1[CH2:16][CH2:17][CH:12]([N:6]2[C:5]3[CH:18]=[CH:19][C:2]([F:1])=[CH:3][C:4]=3[N:8]([CH2:9][CH3:10])[C:7]2=[O:11])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 133659801,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxideHCID 186960004-(5-Fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidine

Product 1

HCID 100758171,1-Dioxido-2-(4-(4-(5-fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)butyl)-5-chloro-1,2-benzisothiazol-3(2H)-one

Procedure

Starting with 4-(5-fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidine and 1,1-dioxido-2-(4-bromobutyl)-5-chloro-1,2-benzisothiazol-3(2H)-one and following the procedure of Example 1, the title compound was obtained as the HCl salt, melting point 266-268° C. The NMR was consistent with the structure.

Sources & evidence

ORD record
ord-a9a542dd8dee44bb9f7ba390dfc5a1c3
Source dataset
uspto-grants-1999_09
Patent number
US05952351

Reaction notes

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