O-Toluidine → HCID 21850864, compound

Participants

Reaction Steps

Ethyl 4-methanesulfonyloxy-8-methoxy-1,7-naphthyridin-3-carboxylate (261 mg and o-toluidine (0.17 nl) were dissolved into 7 ml of acetonitrile and the solution was heated to reflex for 30 minutes. After cooling the mixture, the solvent was evaporated under reduced pressure and the beside was dissolved into chloroform. The solution was washed with water and then saturated sodium bicarbonate, dried, and concentrate under reduced pressure. The residue was subjected to silica gel column chromatography using a mixture of hexane:ethyl acetate (2:1) as an eluant to give yellow titled compound (180 mg, 67%).

Provenance & Evidence