O-Toluidine → HCID 21850850, compound

Participants

Reaction Steps

3-Butyryl-4-methanesulfonyloxy-8-methoxy-1,7-naphthyridine (259 mg) and o-toluidine (0.17 ml) were dissolved into 7 ml of acetonitrile, and the solution was extracted with chloroform, and the organic phase was washed with water and then saturated sodium bicarbonate. After drying, and concentration under reduced pressure, the resulting residue was subjected to silica gel column chromatography using a mixture of hexane:ethyl acetate (1:1) as an eluant to give yellow titled compound (150 mg, 56%).

Provenance & Evidence