O-Toluidine → HCID 21850857, compound

HRID 618451Notes

Reaction equation

HRID 618451 reaction equation
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1OS(C)(=O)=O)=[CH:13][CH:12]=[N:11][C:10]=2[CH:21]([CH3:23])[CH3:22])(=[O:5])[CH2:2][CH2:3][CH3:4].[NH2:24][C:25]1[C:26]([CH3:31])=[CH:27][CH:28]=[CH:29][CH:30]=1>>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH3:31])=[CH:13][CH:12]=[N:11][C:10]=2[CH:21]([CH3:23])[CH3:22])(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 7242O-ToluidineHCID 21850853HCID 21850853, compound

Product 1

HCID 21850857HCID 21850857, compoundYield 58%

Procedure

By following a similar procedure described in Example 33(B) using 3-Butyryl-8-isopropyl-4-methanesulfonyloxy-1,7-naphthyridine (282 mg) and o-toluidine (0.17 ml) to give the titled compound (168 mg, 58%).

Sources & evidence

ORD record
ord-dab9c32e33ca4ef8b9e613ac40775390
Source dataset
uspto-grants-1999_09
Patent number
US05952504

Reaction notes

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