1-Benzylpiperazine → HCID 131721375, compound

HRID 618504Notes

Reaction equation

[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([C:26]5[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=5)=[C:18]4[O:21][CH2:22]OCC)=[CH:13][C:12]=3[O:35]C)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH2:37]([N:44]1[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]1)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[CH2:37]([N:44]1[CH2:49][CH2:48][NH:47][CH2:46][CH:45]1[C:30](=[O:31])[C:29]1[CH:28]=[CH:27][C:26]([C:17]2[CH:16]=[CH:15][C:14]3[C:19](=[CH:20][C:11]([C:1]45[CH2:8][CH:7]6[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]6)[CH2:2]4)[CH2:10]5)=[C:12]([O:35][CH2:17][CH2:18][O:21][CH3:22])[CH:13]=3)[C:18]=2[O:21][CH3:22])=[CH:34][CH:33]=1)[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

Reactant 2

HCID 759941-Benzylpiperazine

HCID 131721376HCID 131721376, compound

Product 1

HCID 131721375HCID 131721375, compoundYield 64.6%

Procedure

Following the procedure of Example 27(b), but reacting 7.3 g (14.4 mmol) of 4-[7-(1-adamantyl)-6-methoxy-ethoxymethoxy-2-naphthyl]benzoic acid chloride with 2.5 ml (14.4 mmol) of 4-benzylpiperazine, 3 g (33%) of the expected compound were obtained, which compound had a melting point of 176°-7° C.

Sources & evidence

ORD record: ord-2ec71198b0ba46b4810aa5139275754e
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05952382

Reaction notes

Loading…