Lithium Bromide → (13E)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[1-(3-phenyloxiran-2-yl)ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

Participants

Reaction Conditions

Reaction Steps

To a solution of Cryptophycin 8 (20 mg) in 1.0 mL of dry acetone(distilled from K2CO3) was added 20 mg of LiBr. The mixture was stirred for 24 h at 90° C. After cooling to room temperature, the solvent was evaporated and the residue was subjected to normal-phase HPLC using 50/50 EtOAc/hexane to give Cryptophycin 25 (5.2 mg) and Cryptophycin 37 (4.2 mg).

Provenance & Evidence