HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618589Generated: October 30, 2026
Lithium Chloride → (13E)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[1-(3-phenyloxiran-2-yl)ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
https://huagongshe.com/reaction/618589
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Cryptophycin 8 | HCID 9918016 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (13E)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[1-(3-phenyloxiran-2-yl)ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone | HCID 5468287 | 35.9% |
Reaction Steps
To a solution of Cryptophycin 8 (20 mg) in 1.0 mL of dry acetone(distilled from K2CO3) was added 20 mg of LiCl. The mixture was stirred for 3 days at 100° C., cooled to room temperature, and evaporated. The residue was subjected to reversed-phase HPLC using 82/18 MeOH/H2O to give Cryptophycin 27 (6.8 mg) and recovered Cryptophycin 8 (10.1 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05952298 |
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| Source dataset | uspto-grants-1999_09 |
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| ORD ID | ord-d79e2bd748ff473bbc55cbb9dcc2a9f0 |
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| Source note | uspto-grants-1999_09 |
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