HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 9852601, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (13E)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[1-(3-phenyloxiran-2-yl)ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone | HCID 5468287 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 9852601 | HCID 9852601 | 53.3% |
Reaction Steps
A solution of Cryptophycin 27 (6.0 mg) in 1.0 mL of dry acetone was treated with 15 mg of potassium carbonate at 85° C. After 24 h the reaction mixture was filtered and the filtrate was evaporated. The residue was subjected to normal-phase HPLC on silica using 50/50 EtOAc/hexane to give Cryptophycin 39 (3.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952298 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-a6c522e7248d4f8590ecf78ab89dfcbe |
| Source note | uspto-grants-1999_09 |