Hydrochloric Acid → HCID 135503193, compound

Participants

Reaction Steps

Friedel-Crafts acylation: In a 500 ml sulfonation flask having a stirrer, dropping funnel, condenser and internal thermometer, 22.9 g (0.1 mol) of 2,4-dichloro-6-(1-methylpyrrol-2-yl)-1,3,5-triazine and 24.2 g (0.22 mol) of resorcinol are initially introduced into 200 ml of xylene (isomer mixture). At 45-50° C., 29.3 g (0.22 mol) of aluminium chloride are slowly introduced and the mixture is stirred at 80-83° C. until the evolution of HCl has ended (about 2 hours). The warm reaction solution is allowed to run into dil. hydrochloric acid with stirring, and the solid is filtered off with suction and washed with acetone/water until neutral. Drying is carried out at 100° C. in vacuo. 30.5 g (81.0% of theory) of 2,4-bis(2,4-dihydroxyphenyl)-6-(1-methylpyrrol-2-yl)-1,3,5-triazine are obtained as a yellow powder (m.p.>300° C.). The structure is in agreement with the 1H-NMR spectrum.

Provenance & Evidence