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HRID618606

反应详情

EQUATION

反应方程式

HRID 618606 的结构方程式

REACTANTS

反应物

1
结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID9903

Lithocholic acid

C24H40O3

PRODUCTS

生成物

1
结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C
HCID9548797

Cholan-24-oic acid

C24H40O2

收率 50%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)OC(C)=O
溶剂HCID7918

Acetic anhydride

C4H6O3

PROCEDURE

实验过程

A solution of 1 g of the lithocholic acid dimer prepared by the inventors, viz. bis(5(-cholan-24-oic-3(-yl) sebacate, in 6 ml of acetic anhydride was heated to 120° C. in an oil bath for 1 h. The solvent was partially removed and the mixed anhydride prepolymer was allowed to crystallize at -10° C. The product was filtered out, washed with a small amount of cold acetic anhydride and dried under vacuum at room temperature for two days. The requested bis (5(-cholan-24-oic acid 3(-yl) sebacate prepolymer (PreLCA) was obtained with a yield of 50%.

WORKUP

后处理

  1. customThe solvent was partially removed
  2. customto crystallize at -10° C
  3. filtrationThe product was filtered out
  4. washwashed with a small amount of cold acetic anhydride
  5. customdried under vacuum at room temperature for two days