HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-nitro-5-fluorophenyl)aminomethanephosphonic acid diethyl ester → N-(2-amino-5-fluorophenyl)aminomethanephosphonic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-nitro-5-fluorophenyl)aminomethanephosphonic acid diethyl ester | HCID 17800777 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(2-amino-5-fluorophenyl)aminomethanephosphonic acid diethyl ester | HCID 15281075 | 92.6% |
Reaction Steps
790 mg of N-(2-nitro-5-fluorophenyl)aminomethanephosphonic acid diethyl ester is mixed in 50 ml of ethanol with 2.5 g of Raney nickel and hydrogenated for 2 hours at room temperature under normal hydrogen pressure. After suctioning-off from the catalyst, it is concentrated by evaporation. 660 mg of N-(2-amino-5-fluorophenyl)aminomethanephosphonic acid diethyl ester is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05955461 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-812e2a3af9ad4128b1f81d6148c8fdac |
| Source note | uspto-grants-1999_09 |