Thionyl Chloride → HCID 54154081, compound

HRID 618648Notes

Reaction equation

HRID 618648 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14]O)[C:8](=[O:16])[C:7](=[O:17])[NH:6]2.S(Cl)([Cl:22])=O>>[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][Cl:22])[C:8](=[O:16])[C:7](=[O:17])[NH:6]2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 217101801,4-Dihydro-1-(2-hydroxyethyl)-6-(trifluoromethyl)-2,3-quinoxalinedione

Product 1

HCID 54154081HCID 54154081, compound

Procedure

1.3 g (4.7 mmol) of 2-[(6 trifluoromethylquinoxaline-2,3-dion-1-yl)ethyl alcohol is stirred in 20 ml of thionyl chloride for 4 hours at room temperature. After concentration by evaporation and subsequent distillation with toluene, 1.34 g (97% of theory) of 2-[(6 trifluoromethylquinoxaline-2,3-dion-1-yl)ethyl chloride is obtained.

Workup

  1. concentrationAfter concentration
  2. customby evaporation and subsequent distillation with toluene, 1.34 g (97% of theory) of 2-[(6 trifluoromethylquinoxaline-2,3-dion-1-yl)ethyl chloride
  3. customis obtained

Sources & evidence

ORD record
ord-ee38dbb19f0c4a3ca7b5d0258d39ee0d
Source dataset
uspto-grants-1999_09
Patent number
US05955461

Reaction notes

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