反应详情

温度

100 °C

To 2-(1-benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid (Compound Z4, 68 mg, 0.22 mmol), polyphosphoric acid (3.5 g) was added, and the mixture was stirred for 1 hr at 100° C. under heating. The mixture was added with water, extracted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (41 mg, 63%).

1. temperatureunder heating
2. extractionextracted with ethyl acetate
3. washwashed with water
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customThe residues obtained
6. concentrationafter concentration under reduced pressure
7. customwere purified by silica gel column chromatography (ethyl acetate/hexane)