Methyl butyrate → HCID 178456762, compound

Participants

Role	Name	HCID	Charge
Reactant	Methyl butyrate	HCID 12180	—
Reactant	pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate	HCID 21847799	—
Reactant	methyl (2S)-2-amino-4-(1H-1,2,3,4-tetrazol-5-yl)butanoate	HCID 178501500	—
Product	HCID 178456762	HCID 178456762	—

Reaction Steps

Using analogous procedures to those described in Example 1 pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate was reacted with methyl (2S)-2-amino-4-(tetrazol-5-yl)butyrate and the resultant methyl butyrate was hydrolysed to give 2- {p-{N-[1-(2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzamido}-4-(tetrazol-5-yl)butyric acid in 25% yields m.p. 207° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05955463
Source dataset	uspto-grants-1999_09
ORD ID	ord-aa05807e024d4971adce787a3e9ef0e8
Source note	uspto-grants-1999_09