HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-methyl-1H-indazole-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1H-Indazole-3-carboxylic acid, 1-methyl- | HCID 689105 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-methyl-1H-indazole-3-carbonyl chloride | HCID 7022055 | 100% |
Reaction Steps
A stirred suspension of 1-methyl-indazole-3-carboxylic acid (0.68 g, 3.86 mol) in anhydrous ether (50 ml) was treated with thionyl chloride (0.28 ml, 3.84 mol) and a few drops of dimethylformamide. After stirring for one hour the solid dissolved. The solvent was evaporated to give 1-methyl-indazole-3-carbonyl chloride as a yellow solid (0.75 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05955470 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-923295db56744aadb0630742fbec9dfe |
| Source note | uspto-grants-1999_09 |