3,4-Dichloroaniline → HCID 21847841, compound

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Reaction Steps

A mixture of 4-chloro-6-fluoroquinazoline (2 g), 3,4-dichloroaniline (1.78 g) and isopropanol (30 ml) was heated at reflux for 2 hours. The resulting solid was filtered off, washed with isopropanol and with diethyl ether to give 4-(3,4-dichloroanilino)-6-fluoroquinazoline hydrochloride (3.2 g), m.p. >300° C.; NMR Spectrum: (CD3SOCD3) 7.74 (d, 1H), 7.88 (m, 1H), 8.07 (m, 2H), 8.24 (d, 1H), 8.97 (m, 1H), 8.98 (s, 1H);

Provenance & Evidence