HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluoroaniline → 4-(3,4-Difluoroanilino)-6-(1-imidazolyl)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Reactant | 4-Chloro-6-(1-imidazolyl)quinazoline | HCID 21847835 | — |
| Product | 4-(3,4-Difluoroanilino)-6-(1-imidazolyl)quinazoline | HCID 21847847 | 35% |
Reaction Steps
Using an analogous procedure to that described in Example 4, 4-chloro-6-(1-imidazolyl)quinazoline was reacted with 3,4-difluoroaniline to give 4-(3,4-difluoroanilino)-6-(1-imidazolyl)quinazoline in 35% yield, NMR Spectrum: (CD3SOCD3) 7.2 (s, 1H), 7.4-7.7 (m, 3H), 7.95 (d, 1H), 8.1 (m, 1H), 8.2 (m, 1H), 8.4 (s, 1H), 8.65 (s, 1H), 8.7 (d, 1H), 9.7 (broad s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05955464 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-0f22b3efe69f4f709e6da41e17c309af |
| Source note | uspto-grants-1999_09 |