3-Chloro-4-fluoroaniline → HCID 21847807, compound

HRID 618677Notes

Reaction equation

HRID 618677 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH:16]=[CH:15][N:14]=[C:13]3[CH3:17])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[F:26])[NH2:22]>>[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[F:26])[NH:22][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH:16]=[CH:15][N:14]=[C:13]3[CH3:17])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 97083-Chloro-4-fluoroanilineHCID 21847808HCID 21847808, compound

Product 1

HCID 21847807HCID 21847807, compoundYield 10%

Procedure

Using an analogous procedure to that described in Example 4, 4-chloro-6-(2-methylimidazol-1-yl)quinazoline was reacted with 3-chloro-4-fluoroaniline to give 4-(3-chloro-4-fluoroanilino)-6-(2-methylimidazol-1-yl)quinazoline in 10% yield: NMR Spectrum: (CD3SOCD3) 2.4 (s, 3H), 7.0 (d, 1H), 7.4 (m, 2H), 7.6 (m, 1H), 7.95 (d, 2H), 8.2 (m, 1H), 8.6 (s, 1H), 8.7 (s, 1H), 9.7 (broad s, 1H).

Sources & evidence

ORD record
ord-e9f95fcf78f44fcda20bb824c22fe68d
Source dataset
uspto-grants-1999_09
Patent number
US05955464

Reaction notes

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