反应详情

3-Fluorobenzonitrile (25 g) was added dropwise to a stirred mixture of potassium nitrate (21.1 g) and concentrated sulphuric acid (150 ml) which had been cooled in a mixture of salt and ice. The mixture was stirred at ambient temperature for 45 minutes. The mixture was poured onto ice (800 ml) and the precipitate was isolated. The solid so obtained was dissolved in methylene chloride, dried (MgSO4) and the solution was evaporated to give 5-fluoro-2-nitrobenzonitrile (19 g).

1. temperaturehad been cooled in a mixture of salt and ice
2. additionThe mixture was poured onto ice (800 ml)
3. customthe precipitate was isolated
4. customThe solid so obtained
5. dry with materialdried (MgSO4)
6. customthe solution was evaporated