Thiophosgene → 4-(3-Chloro-4-fluoroanilino)-6-isothiocyanato-7-methoxyquinazoline

Participants

Role	Name	HCID	Charge
Reactant	Thiophosgene	HCID 10040	—
Reactant	N4-(3-Chloro-4-fluorophenyl)-7-methoxy-4,6-quinazolinediamine	HCID 21847826	—
Solvent	Hydrochloric Acid	HCID 313	—
Product	4-(3-Chloro-4-fluoroanilino)-6-isothiocyanato-7-methoxyquinazoline	HCID 21847839	—

Reaction Steps

After repetition of the previous steps, thiophosgene (0.5 ml) was added dropwise to a stirred solution of 6-amino4-(3-chloro-4-fluoroanilino)-7-methoxyquinazoline (1.65 g) in 2N aqueous hydrochloric acid (45 ml). The mixture was stirred at ambient temperature for 16 hours. The precipitate was isolated and dried to give 4-(3-chloro-4-fluoroanilino)-6-isothiocyanato-7-methoxyquinazoline which was used without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05955464
Source dataset	uspto-grants-1999_09
ORD ID	ord-f5e3aaaa7703448aa3a8e47b38958f2d
Source note	uspto-grants-1999_09