Ammonium Hydroxide → 4-(4-Benzoyl-3-chloroanilino)-6-(1-imidazolyl)-quinazoline

Participants

Reaction Steps

Using an analogous procedure to that described in Example 4 except that the reaction product was basified by treatment with a saturated aqueous sodium bicarbonate solution rather than with a concentrated aqueous ammonium hydroxide solution, 4-chloro-6-(1-imidazolyl)quinazoline was reacted with 4-amino-2-chlorobenzophenone to give 4-(4-benzoyl-3-chloroanilino)-6-(1-imidazolyl)-quinazoline in 11% yield, m.p. 220-223° C.; NMR Spectrum: (CD3SOCD3) 7.2 (s, 1H), 7.5-7.8 (m, 6H), 7.9 (s, 1H), 8.0 (d, 1H), (m, 1H), 8.25 (m, 1H), 8.3 (d, 1H), 8.4 (s, 1H), 8.78 (s, 1H), 8.8 (d, 1H), 10.0 (broad s, 1H);

Provenance & Evidence