Isopropanol → HCID 21847836, compound

Participants

Reaction Steps

A mixture of 4-chloro-6-(1,2,4-triazol-1-yl)quinazoline (0.54 g), 3-chloro-4-fluoroaniline (0.34 g) and isopropanol (25 ml) was stirred and heated to reflux for 2 hours. The mixture was cooled to ambient temperature, acetone (20 ml) was added and the mixture was filtered. The solid so obtained was washed with acetone and dried to give 4-(3-chloro-4-fluoroanilino)-6-(1,2,4-triazol-1-yl)quinazoline hydrochloride salt (0.61 g), m.p. >250° C.; NMR Spectrum: (CD3SOCD3) 7.49 (t, 1H), 7.8 (m, 1H), 8.03-8.08 (m, 2H), 8.33 (s, 1H), 8.52 (m, 1H), 8.93 (s, 1H), 9.62 (m, 2H);

Provenance & Evidence