Dimethyl Sulfoxide → 2-Nitro-5-(1,2,4-triazol-1-yl)benzonitrile

Participants

Role	Name	HCID	Charge
Reactant	Dimethyl Sulfoxide	HCID 679	—
Reactant	Triethylamine	HCID 8471	—
Reactant	1H-1,2,4-Triazole	HCID 9257	—
Reactant	5-Fluoro-2-nitrobenzonitrile	HCID 3756467	—
Solvent	Water	HCID 962	—
Product	2-Nitro-5-(1,2,4-triazol-1-yl)benzonitrile	HCID 21847814	48.9%

Reaction Conditions

Temperature	85 °C

Reaction Steps

A mixture of 5-fluoro-2-nitrobenzonitrile (3 g), 1,2,4-triazole (4.92 g), triethylamine (9.9 ml) and DMSO (50 ml) was stirred and heated to 85° C. for 16 hours. The mixture was cooled to ambient temperature and water was added. The precipitate was isolated and dried to give 2-nitro-5-(1,2,4-triazol-1-yl)benzonitrile (1.9 g) which was used without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05955464
Source dataset	uspto-grants-1999_09
ORD ID	ord-349c67f423c24cd69dd63425a6f5d688
Source note	uspto-grants-1999_09