反应详情

温度

40 °C

Chlorosulfonic acid (87 ml) was added dropwise to ethyl phenylacetate (48 g), and the mixture was stirred at 40° C. for 30 minutes. The reaction mixture was poured into ice water (1000 ml), and the separated oily substance was extracted with methylene chloride. The methylene chloride layer was washed successively with water and a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure gave ethyl 4-chlorosulfonylphenylacetate (42 g).

1. extractionthe separated oily substance was extracted with methylene chloride
2. washThe methylene chloride layer was washed successively with water
3. dry with materiala saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate
4. customEvaporation of the solvent under reduced pressure