Dicyclohexylcarbodiimide → HCID 15859752, compound

Participants

Reaction Steps

A solution of 0.3 g (0.78 mmol) of 5-[ethylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoic acid, 0.11 g (0.78 mmol) of HOBT and 0.18 g (0.86 mmol) of DCC in 4 ml of DMF is stirred at 0° C. for 1 h. 0.09 g (0.78 mmol) of diethylaminoethylamine is then added and the mixture is stirred overnight at RT. It is treated with 50 ml of water and 50 ml of EA, and the organic phase is washed twice with 25 ml each of saturated sodium bicarbonate solution and additionally twice with water. After drying over magnesium sulfate and concentrating in vacuo, 0.3 g of 5-[ethylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoic acid (2-diethylaminoethyl)amide is obtained.

Provenance & Evidence