Diethylene Glycol Monoethyl Ether → HCID 86754516, compound

Participants

Reaction Steps

A solution of 0.5 g (1.35 mmol) of [(2,2-diethyl-6-methylchroman-4-yl)ethylsulfonylamino]acetic acid, 0.2 g (1.5 mmol) of diethylene glycol monoethyl ether, 0.31 g (1.5 mmol) of DCC and 2 mg (0.01 mmol) of DMAP in 7 ml of methylene chloride is stirred overnight at RT. It is washed successively with 5% strength acetic acid, saturated sodium bicarbonate solution and water, dried over magnesium sulfate and concentrated in vacuo. After subsequent purification by chromatography using cyclohexane/EA 4:1, 0.29 g of 2-(2-ethoxyethoxy)ethyl [(2,2-diethyl-6-methylchroman-4-yl)ethylsulfonylamino]acetate is obtained as a viscous oil.

Provenance & Evidence