Dicyclohexylcarbodiimide → HCID 21848657, compound

Participants

Reaction Steps

A solution of 0.5 g (1.35 mmol) of 5-[methylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoic acid, 0.25 g (1.5 mmol) of 2-(N-benzyl-N-methylamino)ethanol, 0.31 g (1.5 mmol) of DCC and a spatula tipful of DMAP in 10 ml of methylene chloride is stirred overnight at RT. After filtering off the precipitate, the solution is concentrated and the crude product is purified by chromatography on silica gel using methylene chloride/methanol 97:3, and 0.45 g of 2-(benzylmethylamino)ethyl 5-[methanesulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoate is obtained.

Provenance & Evidence