1,1'-Carbonyldiimidazole → HCID 17786696, compound

Participants

Reaction Steps

A mixture of 0.5 g (1.4 mmol) of 5-[methylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoic acid (Example 10c) and 0.26 g (1.6 mmol) of CDI in 20 ml of THF is stirred at RT for 3 h. 0.2 g (1.6 mmol) of 2-(2-aminoethyl)-pyridine is then added and the mixture is stirred further overnight at RT. After concentrating the reaction mixture, the residue is taken up in EA and water, and the organic phase is washed 3 times with 2M sodium hydroxide solution. After drying over magnesium sulfate, concentration and purification by chromatography on silica gel using methylene chloride/methanol 9:1, 0. 0.33 g of 5-[methylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]-pentanoic acid (2-(2-pyridyl)ethyl)amide is obtained.

Provenance & Evidence