Water → HCID 21848650, compound

Participants

Reaction Steps

5.7 g (12 mmol) of ethyl 4-[(6-benzyloxy-2,2-dimethylchroman-4-yl)-methanesulfonylamino]-N-butyrate (Ex. 28f) were treated with 10 ml of 1 M lithium aluminum hydride solution in THF in 100 ml of THF at 0° C. The mixture was treated at RT with a little water, then with 1N hydrochloric acid, and concentrated, and the residue was extracted three times using EA. After drying and concentrating, the product crystallized overnight. 4.9 g were obtained, m.p. 113-115° C. (from PE/DIPE)

Provenance & Evidence