HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Butoxy-2,2-dimethylchroman-4-one oxime → 4-Amino-6-butoxy-2,2-dimethylchroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Butoxy-2,2-dimethylchroman-4-one oxime | HCID 86754519 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Amino-6-butoxy-2,2-dimethylchroman | HCID 21848656 | 72.2% |
Reaction Steps
A solution of 30 g of 6-butoxy-2,2-dimethylchroman-4-one oxime in 500 ml of methanol, 500 ml of THF and 30 ml of ammonia solution was hydrogenated in a shaking duck for 8 h in the presence of Raney nickel. After filtering off the catalyst and concentrating in vacuo, 20.5 g of 4-amino-6-butoxy-2,2-dimethylchroman were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05955607 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-8d871723d87446baa2b9ca4469202214 |
| Source note | uspto-grants-1999_09 |