Methanesulfonyl chloride → (2-Fluoropyridin-4-yl)methyl methanesulfonate

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	(2-Fluoropyridin-4-yl)methanol	HCID 11332468	—
Solvent	Dichloromethane	HCID 6344	—
Product	(2-Fluoropyridin-4-yl)methyl methanesulfonate	HCID 10488448	77%

Reaction Conditions

Temperature	0 °C

Reaction Steps

(2-Fluoropyridin-4-yl) methanol (1 g) was dissolved in DCM (40 ml), added with TEA (3.3 ml) and mesyl chloride (0.67 ml), and the mixture was stirred at 0° C. for 1 hr. The mixture was concentrated and then purified by silica gel column (n-hexane/ethyl acetate=4/1) to obtain the title compound (1.18 g, 77%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09440922B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-d32690f3365648ecbf48da9b44defd66
Source note	uspto-grants-2016_09