Cyclobutanone → HCID 66835163, compound

HRID 61890Notes

Reaction equation

[CH3:1][C:2]1([CH3:28])[C:14]2[NH:13][C:12]3[N:11]=[C:10]([C:15]#[N:16])[CH:9]=[CH:8][C:7]=3[C:6]=2[C:5](=[O:17])[C:4]2[CH:18]=[CH:19][C:20]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[CH:21][C:3]1=2.[C:29]1(=O)[CH2:32][CH2:31][CH2:30]1>>[CH:29]1([N:25]2[CH2:24][CH2:23][N:22]([C:20]3[CH:19]=[CH:18][C:4]4[C:5](=[O:17])[C:6]5[C:7]6[CH:8]=[CH:9][C:10]([C:15]#[N:16])=[N:11][C:12]=6[NH:13][C:14]=5[C:2]([CH3:28])([CH3:1])[C:3]=4[CH:21]=3)[CH2:27][CH2:26]2)[CH2:32][CH2:31][CH2:30]1

Participants

Reactant 2

HCID 14496Cyclobutanone

HCID 66835180HCID 66835180, compound

Product 1

HCID 66835163HCID 66835163, compound

Procedure

According to the method used for synthesizing Compound B3-32, 10,10-dimethyl-5-oxo-8-piperazin-1-yl-10,11-dihydro-5H-1,11-diaza-benzo[b]fluorene-2-carbonitrile was subjected to reductive amination with cyclobutanone to obtain the title compound.

Sources & evidence

ORD record: ord-e1066e6010d44c2a85a0c433919e3b9a
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440922B2

Reaction notes

Loading…