HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Cryptophycin 8
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Cryptophycin | HCID 6438401 | — |
| Solvent | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| Product | Cryptophycin 8 | HCID 9918016 | — |
Reaction Steps
To a solution of 3.8 mg of Cryptophycin 1 in 1.5 mL of 2:1 1,2-dimethoxyethane/water was added 9μL 1N HCl. The solution was allowed to stir at room temperature for 4 h, neutralized with potassium carbonate, and evaporated. The residue was partitioned between water and CH2Cl2. The CH2Cl2 -soluble material was purified by reversed-phase HPLC to obtain 3.3 mg of pure Cryptophycin 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05955423 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-efddc49cfe544ef6b70195fd033f0b81 |
| Source note | uspto-grants-1999_09 |