Ammonium Hydroxide → HCID 88278296, compound

Participants

Reaction Steps

A solution of the compound of Example 15 (300 mg, 0.25 mmol) in DI water (10 mL) is treated with gadolinium acetate (212 mg, 0.52 mmol) at ambient temperature, while the pH is maintained at 5.6-6.0 using 1N ammonium hydroxide solution. When the pH becomes steady, the temperature is elevated to 50° C., and the mixture is stirred for 5 days. The solvent is removed by rotary evaporation, and the residue reconcentrated from DI water (5×200 mL). The crude complex is desalted using preparative HPLC to yield the title compound as a white solid after lyophilization.

Provenance & Evidence