Sodium Hydroxide → HCID 21844899, compound

HRID 618919Notes

Reaction equation

HRID 618919 reaction equation
[I:1][C:2]1[C:7]([C:8]([NH:10][CH2:11][CH:12]([O:18]C(=O)C)[CH2:13][O:14]C(=O)C)=[O:9])=[C:6]([I:22])[C:5]([C:23]([NH:25][CH2:26][CH:27]([O:33]C(=O)C)[CH2:28][O:29]C(=O)C)=[O:24])=[C:4]([I:37])[C:3]=1[NH:38][C:39]([NH:41][C:42]1[C:47]([I:48])=[C:46]([C:49]([NH:51][CH2:52][CH:53]([O:59]C(=O)C)[CH2:54][O:55]C(=O)C)=[O:50])[C:45]([I:63])=[C:44]([C:64]([NH:66][CH2:67][CH:68]([O:74]C(=O)C)[CH2:69][O:70]C(=O)C)=[O:65])[C:43]=1[I:78])=[O:40].[OH-].[Na+]>O.CO>[I:1][C:2]1[C:7]([C:8]([NH:10][CH2:11][CH:12]([OH:18])[CH2:13][OH:14])=[O:9])=[C:6]([I:22])[C:5]([C:23]([NH:25][CH2:26][CH:27]([OH:33])[CH2:28][OH:29])=[O:24])=[C:4]([I:37])[C:3]=1[NH:38][C:39]([NH:41][C:42]1[C:47]([I:48])=[C:46]([C:49]([NH:51][CH2:52][CH:53]([OH:59])[CH2:54][OH:55])=[O:50])[C:45]([I:63])=[C:44]([C:64]([NH:66][CH2:67][CH:68]([OH:74])[CH2:69][OH:70])=[O:65])[C:43]=1[I:78])=[O:40]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 21844910HCID 21844910, compound

Product 1

HCID 21844899HCID 21844899, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

N,N'-bis[2,4,6-triiodo-3,5-bis(2,3-diacetoxypropylaminocarbonyl)phenyl]-urea (4.0 g, 2.26 mmol) was dissolved in a 1:1 mixture of water and methanol (25 ml) containing NaOH (1.44 g, 36 mmol). After stirring for 6 h at 40° C., the solution was treated with a strongly acidic ion exchange resin (Amberlyst 15), the solvent was separated and evaporated to give pure product. Yield: 3.24 g (100%).

Workup

  1. additionthe solution was treated with a strongly acidic ion exchange resin (Amberlyst 15)
  2. customthe solvent was separated
  3. customevaporated
  4. customto give pure product

Sources & evidence

ORD record
ord-4a909dfb26ef4cb9a14a04496f2e4b98
Source dataset
uspto-grants-1999_09
Patent number
US05958376

Reaction notes

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